期刊
BIOINTERPHASES
卷 11, 期 1, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1116/1.4939040
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资金
- Sander Stiftung [D10051281]
- German Research Foundation [SFB 873]
- Cluster of Excellence RESOLV [EXC 1069]
Hyaluronans are a class of glycosaminoglycans that are widespread in the mammalian body and serve a variety of functions. Their most striking characteristic is their pronounced hydrophilicity and their capability to inhibit unspecific adhesion when present at interfaces. Catch-bond interactions are used by the CD44 receptor to interact with this inert material and to roll on the surfaces coated with hyaluronans. In this minireview, the authors discuss the general properties of hyaluronans and the occurrence and relevance of the CD44 catch-bond interaction in the context of hematopoiesis, cancer development, and leukemia. (C) 2016 American Vacuum Society.
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