期刊
BIOSENSORS & BIOELECTRONICS
卷 150, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.111926
关键词
DNA silver nanoclusters; Label free; Biosensor; Fluorescence; Electrochemiluminescence
类别
资金
- National Natural Science Foundation of China [31601552]
- National Key Research and Development Program of China [2017YFC1601704, 2018YFC1602300]
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180509]
- Hong Kong Scholar program
DNA-templated silver nanoclusters (DNA-AgNCs) have demonstrated pervasive applications in analytical chemistry recently. As a way of signal output in DNA-based detection methods, DNA-AgNCs have prominent advantages: first, the recognition and synthesizing sequences are naturally integrated in one DNA probe without any chemical modification or connection; second, the emissive wavelength of DNA-AgNCs can be adjusted in a wide range by employing different sequences; third, DNA-AgNCs can be utilized for producing not only fluorescence, also electrochemiluminescence and electrochemical signals. Besides, they also show potential applications for cell imaging, and are considered to be one of the most ideal nanomaterials for in-vivo imaging due to their ultra-small particle size. In this review, a brief and comprehensive introduction of DNA-AgNCs is firstly given, then label-free probes using DNA-AgNCs are classified and summarized, lastly concluding perspectives are provided on the defects and application potentials.
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