期刊
BIOPHYSICAL JOURNAL
卷 118, 期 2, 页码 415-421出版社
CELL PRESS
DOI: 10.1016/j.bpj.2019.11.025
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资金
- Knut and Alice Wallenberg Foundation for an Academy Fellowship
- Academy of Finland [296135]
- Jane and Aatos Erkko Foundation
- Swedish Research Council [201504614]
- Knut and Alice Wallenberg Foundation (NMR for Life)
- Science for Life Laboratory (SciLifeLab)
- Academy of Finland (AKA) [296135, 296135] Funding Source: Academy of Finland (AKA)
Phytochromes sense red/far-red light and control many biological processes in plants, fungi, and bacteria. Although the crystal structures of dark- and light-adapted states have been determined, the molecular mechanisms underlying photoactivation remain elusive. Here, we demonstrate that the conserved tongue region of the PHY domain of a 57-kDa photosensory module of Deinococcus radiodurans phytochrome changes from a structurally heterogeneous dark state to an ordered, light-activated state. The results were obtained in solution by utilizing a laser-triggered activation approach detected on the atomic level with high-resolution protein NMR spectroscopy. The data suggest that photosignaling of phytochromes relies on careful modulation of structural heterogeneity of the PHY tongue.
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