期刊
BIOINFORMATICS
卷 33, 期 4, 页码 471-474出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv602
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资金
- Innovative Medicines Initiative Joint Undertaking [115006]
- European Union's 7th Framework Programme
- EFPIA companies'
- European Research Council (EU 7th Framework Programme) [269045]
- European Research Council (ERC) [269045] Funding Source: European Research Council (ERC)
Motivation: Depletion of loss-of-function (LoF) mutations may provide a rank of genic functional intolerance and consequently susceptibility to disease. Results: Here we have studied LoF mutations in 60 706 unrelated individuals and show that the most intolerant quartile of ranked genes is enriched in rare and early onset diseases and explains 87% of de novo haploinsufficient OMIM mutations, 17% more than any other gene scoring tool. We detected particular enrichment in expression of the depleted LoF genes in brain (odds ratio =1.5; P-value = 4.2e -07). By searching for de novo haploinsufficient mutations putatively associated with neurodevelopmental disorders in four recent studies, we were able to explain 81% of them. Taken together, this study provides a novel gene intolerance ranking system, called LoFtool, which may help in ranking genes of interest based on their LoF intolerance and tissue expression. Availability and implementation: The LoFtool gene scores are available in the Supplementary data.
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