期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 28, 期 2, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2019.115233
关键词
Terpenoid; Marine sponge; Cell-cycle; Structure elucidation
资金
- JSPS KAKENHI [17H06403]
- Grants-in-Aid for Scientific Research [17H06403] Funding Source: KAKEN
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.
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