期刊
BIOGERONTOLOGY
卷 21, 期 2, 页码 155-171出版社
SPRINGER
DOI: 10.1007/s10522-019-09849-8
关键词
Mitochondria; Drosophila melanogaster; Reactive oxygen species; Antioxidant defence; Stress resistance
资金
- Ministry of Education and Science of Ukraine [0115U002304, 0117U006426]
- Academy of Finland (FinMIT Centre of Excellence Grant) [272376]
- European Research Council [232738]
- European Research Council (ERC) [232738] Funding Source: European Research Council (ERC)
Mitochondrial alternative NADH dehydrogenase (aNDH) was found to extend lifespan when expressed in the fruit fly. We have found that fruit flies expressing aNDH from Ciona intestinalis (NDX) had 17-71% lifespan prolongation on media with different protein-tocarbohydrate ratios except NDX-expressing males that had 19% shorter lifespan than controls on a high protein diet. NDX-expressing flies were more resistant to organic xenobiotics, 2,4-dichlorophenoxyacetic acid and alloxan, and inorganic toxicant potassium iodate, and partially to sodium molybdate treatments. On the other hand, NDX-expressing flies were more sensitive to catechol and sodium chromate. Enzymatic analysis showed that NDX-expressing males had higher glucose 6-phosphate dehydrogenase activity, whilst both sexes showed increased glutathione S-transferase activity.
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