期刊
BIOCONJUGATE CHEMISTRY
卷 30, 期 11, 页码 2967-2973出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.9b00661
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- Ministere de l'Enseignement Superieur, de la Recherche et de l'Innovation
One hallmark of protein chemical synthesis is its capacity to access proteins that living systems can hardly produce. This is typically the case for proteins harboring post-translational modifications such as ubiquitin or ubiquitin-like modifiers. Various methods have been developed for accessing polyubiquitin conjugates by semi- or total synthesis. Comparatively, the preparation of small-ubiquitin-like modifier (SUMO) conjugates, and more particularly of polySUMO scaffolds, is much less developed. We describe hereinafter a synthetic strategy for accessing all SUMO-2/3 dimer combinations.
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