期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1866, 期 3, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2019.165591
关键词
Congenital; Chagas; Vaccine; Trypanosoma cruzi; Maternal-fetal transmission
资金
- CONICET, Argentina [PUE 22920170100106CO]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI054578, R01AI136031]
Trypanos o ma cruzi (T cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission of Tc and provide a justification for the investment in the development of vaccines against congenital CD.
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