A sustainable approach for the downstream processing of bacterial polyhydroxyalkanoates: State-of-the-art and latest developments

Bioplastics have emerged as a platform to reduce our dependence on fossil fuels. Polyhydroxyalkanoates (PHAs) are a family of biodegradable polyesters with large potential in consumer goods and medical applications. These polymers accumulate in prokaryotic microbes and their recovery is a challenging, often under explored, operation. In the past, oil-derived solvents and chemicals have been widely used as extracting agents, compromising the environmentally-friendly claim of bioplastics. Furthermore, the large amount of chemicals and solvents required at the industrial level would negatively impact the economics of the process. The present review presents the latest advances in the field of downstream operations for PHA recovery emphasizing those green technologies with scaling-up feasibility. As for the upstream and fermentation stages, the extraction process needs to be carefully optimized to accomplish a competitive production of PHAs.