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Masters of Longevity: Lessons from Long-Lived Bivalves - A Mini-Review
Eva E. R. Philipp et al.
GERONTOLOGY (2010)
Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1
Soeren Mai et al.
JOURNAL OF CELL SCIENCE (2010)
New insights into the role of mitochondria in aging: mitochondrial dynamics and more
Arnold Y. Seo et al.
JOURNAL OF CELL SCIENCE (2010)
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Ji-Hong Lim et al.
MOLECULAR CELL (2010)
Hypoxia-inducible factor-2 alpha is a catabolic regulator of osteoarthritic cartilage destruction
Siyoung Yang et al.
NATURE MEDICINE (2010)
Heat shock factors: integrators of cell stress, development and lifespan
Malin Akerfelt et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans
Cormac T. Taylor et al.
PHYSIOLOGY (2010)
Regulatory role of HIF-1 alpha in the pathogenesis of age-related macular degeneration (AMD)
Olli Arjamaa et al.
AGEING RESEARCH REVIEWS (2009)
Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain
Obinna I. Ndubuizu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2009)
Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation
Kun-yong Kim et al.
CANCER RESEARCH (2009)
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Francesco Colotta et al.
CARCINOGENESIS (2009)
TOR-driven aging Speeding car without brakes
Mikhail V. Blagosklonny
CELL CYCLE (2009)
The active form of the metabolic sensor AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis
Alejandro Vazquez-Martin et al.
CELL CYCLE (2009)
Hypoxia inducible factor-2α: a critical mediator of aggressive tumor phenotypes
Guoliang Qing et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
Jose Miguel Lopez-Novoa et al.
EMBO MOLECULAR MEDICINE (2009)
Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation
Beatriz E. Rendon et al.
EXPERIMENTAL AND MOLECULAR PATHOLOGY (2009)
HIF-1 in the inflammatory microenvironment
Nathalie Dehne et al.
EXPERIMENTAL CELL RESEARCH (2009)
Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging
Qiongqiong Zhou et al.
FEBS LETTERS (2009)
AMPK: Lessons from transgenic and knockout animals
Benoit Viollet et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
David R. Mole et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Xinglong Wang et al.
JOURNAL OF NEUROSCIENCE (2009)
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
Gregory Bellot et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles
Christine M. Clemson et al.
MOLECULAR CELL (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
Yair Benita et al.
NUCLEIC ACIDS RESEARCH (2009)
AMPK in Health and Disease
Gregory R. Steinberg et al.
PHYSIOLOGICAL REVIEWS (2009)
The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans
Yi Zhang et al.
PLOS ONE (2009)
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply
Sven Hoppe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A network biology approach to aging in yeast
David R. Lorenz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mechanisms and evolution of hypoxia tolerance in fish
Milica Mandic et al.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2009)
Heat shock proteins: keys to healthy ageing?
Kenneth J. Rodgers et al.
REDOX REPORT (2009)
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
Elhadji M. Dioum et al.
SCIENCE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Mitochondria in cancer: Not just innocent bystanders
Christian Frezza et al.
SEMINARS IN CANCER BIOLOGY (2009)
Regulation of the aging process by autophagy
Antero Salminen et al.
TRENDS IN MOLECULAR MEDICINE (2009)
NF-κB as a Critical Link Between Inflammation and Cancer
Michael Karin
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans
Di Chen et al.
PLOS GENETICS (2009)
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford et al.
NATURE REVIEWS CANCER (2009)
Activation of innate immunity system during aging: NF-kappa B signaling is the molecular culprit of inflamm-aging
Antero Salminen et al.
AGEING RESEARCH REVIEWS (2008)
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
Anne Simonsen et al.
AUTOPHAGY (2008)
Longevity pathways converge on autophagy genes to regulate He span in Caenorhabditis elegans
Marton L. Toth et al.
AUTOPHAGY (2008)
Essential Role of Developmentally Activated Hypoxia-Inducible Factor 1α for Cardiac Morphogenesis and Function
Jaya Krishnan et al.
CIRCULATION RESEARCH (2008)
FoxO transcription factors in the maintenance of cellular homeostasis during aging
Dervis A. M. Salih et al.
CURRENT OPINION IN CELL BIOLOGY (2008)
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
Marcella Fulco et al.
DEVELOPMENTAL CELL (2008)
The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
Christina Warnecke et al.
EXPERIMENTAL CELL RESEARCH (2008)
Early mitochondrial dysfunction in long-lived Mclk1+/- mice
Jerome Lapointe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation
Mei Yee Koh et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
Edward J. Miller et al.
NATURE (2008)
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Jordi Rius et al.
NATURE (2008)
Direct regulation of TWIST by HIF-1α promotes metastasis
Muh-Hwa Yang et al.
NATURE CELL BIOLOGY (2008)
Brief Report: PHD2 Mutation and Congenital Erythrocytosis with Paraganglioma
Charline Ladroue et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
FOXOs, cancer and regulation of apoptosis
Z. Fu et al.
ONCOGENE (2008)
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
Wei-Lien Yen et al.
PHYSIOLOGY (2008)
Mitochondria in cancer cells: what is so special about them?
Vladimir Gogvadze et al.
TRENDS IN CELL BIOLOGY (2008)
AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus
Takafumi Miyamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis
Kuniko Kimura et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)
HIF-1alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages
Aryan Vink et al.
ATHEROSCLEROSIS (2007)
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
Eric L. Greer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Life and death: Metabolic rate, membrane composition, and life span of animals
A. J. Hulbert et al.
PHYSIOLOGICAL REVIEWS (2007)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
Seungmin Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cellular senescence in cancer and aging
Manuel Collado et al.
CELL (2007)
Anoxia tolerance in turtles: Metabolic regulation and gene expression
Kenneth B. Storey
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2007)
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
Mayka Sanchez et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity
John D. Gordan et al.
CANCER CELL (2007)
Macrophage migration inhibitory factor: A probable link between inflammation and cancer
Richard Bucala et al.
IMMUNITY (2007)
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates -: Possible links between cell metabolism and stabilization of HIF
Peppi Koivunen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
Richard M. Reznick et al.
CELL METABOLISM (2007)
Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization
Millicent Winner et al.
CANCER RESEARCH (2007)
Accumulation of senescent cells in mitotic tissue of aging primates
Jessie C. Jeyapalan et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
Claudio Franceschi et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia
Isabel S. S. Hwang et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2007)
Cancer and ageing: convergent and divergent mechanisms
Manuel Serrano et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
HIF1α delays premature senescence through the activation of MIF
Scott M. Welford et al.
GENES & DEVELOPMENT (2006)
Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1
Young-Sil Yoon et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Oxidative phosphorylation and aging
Edward J. Lesnefsky et al.
AGEING RESEARCH REVIEWS (2006)
The regulation of INK4/ARF in cancer and aging
William Y. Kim et al.
CELL (2006)
Stress resistance in long-lived mouse models
Shin Murakami
EXPERIMENTAL GERONTOLOGY (2006)
Oncogene-induced cell senescence - Halting on the road to cancer
W. J. Mooi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Hypoxia and expression of hypoxia-inducible factor in the aging kidney
Tetsuhiro Tanaka et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2006)
Succinate dehydrogenase and fumarate hydratase:: linking mitochondrial dysfunction and cancer
A. King et al.
ONCOGENE (2006)
Expanding role of AMPK in endocrinology
Blerina Kola et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
Aging networks in Caenorhabditis elegans:: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways
R Curtis et al.
AGING CELL (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Perturbations of the AKT signaling pathway in human cancer
DA Altomare et al.
ONCOGENE (2005)
FOXO transcription factors at the interface between longevity and tumor suppression
EL Greer et al.
ONCOGENE (2005)
The naked mole-rat? A new long-living model for human aging research
R Buffenstein
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2005)
Autophagy and aging -: The importance of maintaining clean cells
Ana Maria Cuervo et al.
AUTOPHAGY (2005)
Body size, energy metabolism and lifespan
JR Speakman
JOURNAL OF EXPERIMENTAL BIOLOGY (2005)
Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart
S Rohrbach et al.
BIOGERONTOLOGY (2005)
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
RG Jones et al.
MOLECULAR CELL (2005)
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
J Campisi
CELL (2005)
The effect of age and calorie restriction on HIF-1-responsive genes in aged liver
MJ Kang et al.
BIOGERONTOLOGY (2005)
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
RJ Appelhoff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation
C Ashur-Fabian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1
EB Kayser et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hypoxic stress tolerance of the blind subterranean mole rat:: Expression of erythropoietin and hypoxia-inducible factor 1α
I Shams et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
HIF-1α induces cell cycle arrest by functionally counteracting Myc
M Koshiji et al.
EMBO JOURNAL (2004)
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
HIF-1α is essential for myeloid cell-mediated inflammation
T Cramer et al.
CELL (2003)
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
HH Zong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
LKB1 - A master tumour suppressor of the small intestine and beyond
LI Yoo et al.
NATURE REVIEWS CANCER (2002)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)
Oxidants, oxidative stress and the biology of ageing
T Finkel et al.
NATURE (2000)
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity
A Rivard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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