Night Shift Work and Risk of Breast Cancer in Women

Background. Night shift work involving circadian disruption has been associated with increased breast cancer rates in some epidemiological studies, but the evidence is still on debate. Aim of the study. The objective of this study is to assess the association between night shift work and breast cancer in Mexican women. Methods. A Case-control study was conducted with incident cases of breast cancer at the Instituto de Seguridad Social del Estado de Mexico y Municipios. Cases were interviewed about past exposures prior to the final diagnosis. Controls were women without breast cancer matched on multiple sociodemographic characteristics. Results. 101 cases and 101 matched controls were interviewed; this small sample size provided consistent, but wide estimates of the assessed associations. The multivariate conditional logistic regression showed that breast-feeding was associated with reduced risk for breast cancer (OR 0.12; 95% CI: 0.02-0.60); women who experienced early menarche (12 years) were more likely to develop breast cancer (OR 18.58; 95% CI 18: 2.19-148). Women who worked at night were more likely to develop breast cancer compared to women who never did (OR = 8.58; 95% CI: 2.19-33.8). Conclusions. Our results are consistent with studies from other countries, which positively associated night shift work with breast cancer. (C) 2019 IMSS. Published by Elsevier Inc.