期刊
BIOFACTORS
卷 42, 期 5, 页码 445-458出版社
WILEY-BLACKWELL
DOI: 10.1002/biof.1279
关键词
mangiferin; C-glycoside; xanthone; biosynthesis; chemical synthesis
资金
- Ministry of Sciences and Technology of China [2012ZX09502-002]
- Natural Science Foundation of China [21432012]
Mangiferin (2C-b-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone C-glycoside occurring in many plant species. Composed of a glucose unit C1fi2 linked to a 1,3,6,7-tetrahydroxyxanthone aglycone, mangiferin exhibits a wide range of biological activities, which recently renewed its interest as a potential pharmacophore. Mangiferin is mainly isolated after extraction procedures from natural sources alongside with its isoforms isomangiferin, homomangiferin, and neomangiferin. However, enzymatic and chemical approaches have been developed to access these phytochemicals, which address the challenging construction of the C-glycosidic linkage. In addition, both approaches have been exploited to modify the aglycone and the sugar moiety in order to afford analogues with specific and improved pharmacological activities. Herein, we provide a comprehensive review on the biosynthesis and chemical synthesis of mangiferin and its congeners. (C) 2016 BioFactors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据