期刊
BIOESSAYS
卷 39, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/bies.201600179
关键词
cell division; cell wall synthesis; cytokinesis; cytoskeleton; dynamics; force generation; FtsZ; signaling
资金
- NIGMS NIH HHS [R01 GM086447] Funding Source: Medline
We propose that the essential function of the most highly conserved protein in bacterial cytokinesis, FtsZ, is not to generate a mechanical force to drive cell division. Rather, we suggest that FtsZ acts as a signal-processing hub to coordinate cell wall synthesis at the division septum with a diverse array of cellular processes, ensuring that the cell divides smoothly at the correct time and place, and with the correct septum morphology. Here, we explore how the polymerization properties of FtsZ, which have been widely attributed to force generation, can also be advantageous in this signal processing role. We suggest mechanisms by which FtsZ senses and integrates both mechanical and biochemical signals, and conclude by proposing experiments to investigate how FtsZ contributes to the remarkable spatial and temporal precision of bacterial cytokinesis. Think again
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