期刊
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
卷 45, 期 6, 页码 606-612出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/apnm-2019-0359
关键词
non-nutritive sweetener; aspartame; sucralose; protocol; glucose metabolism; insulin; glucose; active GLP-1; leptin
资金
- Kuwait Foundation for the Advancement of Sciences (KFAS)
- University Collaborative Research Program (UCRP)
- Canada Research Chairs Program
- Kuwait Civil Service
- Institute for Medical Specialization -Ministry of Health of Kuwait
This study aimed to determine the effect of pure forms of sucralose and aspartame, in doses reflective of common consumption, on glucose metabolism. Healthy participants consumed pure forms of a non-nutritive sweetener (NNS) that were mixed with water and standardized to doses of 14% (0.425 g) of the acceptable daily intake (ADI) for aspartame and 20% (0.136 g) of the ADI for sucralose every day for 2 weeks. Blood samples were collected and analyzed for glucose, insulin, active glucagonlike peptide-1 (GLP-1), and leptin. Seventeen participants (10 females and 7 males; age, 24 +/- 6.8 years; body mass index, 22.9 +/- 2.5 kg/m(2)) participated in the study. The total area under the curve values ofglucose, insulin, active GLP-1 and leptin were similar for the aspartame and sucralose treatment groups compared with the baseline values in healthy participants. There was no change in insulin sensitivity after NNS treatment compared with the baseline values. These findings suggest that daily repeated consumption of pure sucralose or aspartame for 2 weeks had no effect on glucose metabolism among normoglycaemic adults. However, these results need to be tested in studies with longer durations. Novelty Daily consumption of pure aspartame or sucralose for 2 weeks had no effect on glucose metabolism. Daily consumption of pure aspartame or sucralose for 2 weeks had no effect on insulin sensitivity among healthy adults.
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