期刊
BIOESSAYS
卷 38, 期 5, 页码 420-426出版社
WILEY
DOI: 10.1002/bies.201500122
关键词
CenH3; CENP-A; Cse4; FACT; H2A; Z; histone chaperone; histone variant; Psh1; Spt6; Spt16; SWR-C; ubiquitin
资金
- Canadian Institutes for Health Research [MOP-133648]
Histone variants are specialized histones which replace their canonical counterparts in specific nucleosomes. Together with histone post-translational modifications and DNA methylation, they contribute to the epigenome. Histone variants are incorporated at specific locations by the concerted action of histone chaperones and ATP-dependent chromatin remodelers. Recent studies have shown that the histone chaperone FACT plays key roles in preventing pervasive incorporation of two histone variants: H2A.Z and CenH3/CENP-A. In addition, Spt6, another histone chaperone, was also shown to be important for appropriate H2A.Z localization. FACT and Spt6 are both associated with elongating RNA polymerase II. Based on these two examples, we propose that the establishment and maintenance of histone variant genomic distributions depend on a transcription-coupled epigenome editing (or surveillance) function of histone chaperones.
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