期刊
BIOESSAYS
卷 38, 期 10, 页码 991-996出版社
WILEY
DOI: 10.1002/bies.201600110
关键词
AMPK; cancer metabolism; c-Myc; long non-coding RNAs; mTOR; NBR2; tumor suppression
资金
- MD Anderson Cancer Center, Cancer Prevention Research Institute of Texas [RP130020]
- National Institutes of Health [CA181196, CA190370]
- Ellison Medical Foundation [AG-NS-0973-13]
- Gabrielle's Angel Foundation for Cancer Research
Altered cellular metabolism is an emerging hallmark of cancer. Accumulating recent evidence links long non-coding RNAs (lncRNAs), a still poorly understood class of non-coding RNAs, to cancer metabolism. Here we review the emerging findings on the functions of lncRNAs in cancer metabolism, with particular emphasis on how lncRNAs regulate glucose and glutamine metabolism in cancer cells, discuss how lncRNAs regulate various aspects of cancer metabolism through their cross-talk with other macromolecules, explore the mechanistic conceptual framework of lncRNAs in reprogramming metabolism in cancers, and highlight the challenges in this field. A more in-depth understanding of lncRNAs in cancer metabolism may enable the development of novel and effective therapeutic strategies targeting cancer metabolism.
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