期刊
ANTICANCER RESEARCH
卷 39, 期 11, 页码 6087-6095出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.13816
关键词
G3BP1; reactive oxygen species; radio-sensitisation; chemo-sensitization; non-small cell lung cancer
类别
资金
- Korea Institute of Radiological & Medical Sciences (KIRAMS) - Ministry of Science and ICT (MSIT), Republic of Korea [505312019]
Background: RAS GTPase-activating protein-binding protein (G3BP1) is an RNA-binding protein that is essential for assembling stress granules. Many functions related to the survival and progression of cancer have been reported. The current study aimed to investigate the role of G3BP1 in radio-sensitisation of cancer cells. Materials and Methods: Radiation sensitivity and chemosensitivity were analysed in A549 and H460 cells transfected with G3BP1 siRNAs, and N-acetyl-L-cysteine (NAC) was used to elucidate the involvement of reactive oxygen species (ROS). Results: G3BP1 depletion sensitised lung cancer cell lines to radiation, and the effect was related to ROS. G3BP1 depletion impaired the intracellular ROS scavenging system and NAC abolished the radiation-sensitive phenotypes caused by G3BP1 depletion. Conclusion: The study suggested G3BP1 as a promising target for radio- and chemosensitisation of lung cancer.
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