期刊
ANNUAL REVIEW OF PSYCHOLOGY, VOL 71
卷 71, 期 -, 页码 357-387出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-psych-010419-050905
关键词
marmoset; anxiety; subgenual cortex; prefrontal; anterior cingulate; emotion regulation
资金
- Medical Research Council
- Wellcome Trust
Regions of the prefrontal and cingulate cortices play important roles in the regulation of behaviors elicited by threat. Dissecting out their differential involvement will greatly increase our understanding of the varied etiology of symptoms of anxiety. I review evidence for altered activity within the major divisions of the prefrontal cortex, including orbitofrontal, ventrolateral, dorsolateral, and ventromedial sectors, along with the anterior cingulate cortex in patients with clinical anxiety. This review is integrated with a discussion of current knowledge about the causal role of these different prefrontal and cingulate regions in threat-elicited behaviors from experimental studies in rodents and monkeys. I highlight commonalities and inconsistencies between species and discuss the current state of our translational success in relating findings across species. Finally, I identify key issues that, if addressed, may improve that success in the future.
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