期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 82
卷 82, 期 -, 页码 251-273出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021119-034500
关键词
TGF-beta superfamily; epithelium-mesenchymal interaction; esophagus; stomach; intestine; cancer
类别
资金
- US National Institutes of Health [R01 DK113144, DK100342, DK120650]
- Price Family Foundation
The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine.
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