期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 50, 页码 18177-18181出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201908917
关键词
cyclotrimerization; natural products; schinortriterpenoids; structure elucidation; total synthesis
资金
- Marie Sklodowska-Curie actions [702385]
- CNU Office of the Provost
- EPSRC Centre for Doctoral Training in Synthesis for Biology and Medicine [EP/L015838/1]
- AstraZeneca
- Diamond Light Source
- Defence Science and Technology Laboratory
- Evotec
- GlaxoSmithKline
- Janssen
- Novartis
- Pfizer
- Syngenta
- Takeda
- UCB
- Vertex
- EPSRC [EP/M019195/1, EP/E055273/1]
- EPSRC [EP/M019195/1, EP/E055273/1] Funding Source: UKRI
- Marie Curie Actions (MSCA) [702385] Funding Source: Marie Curie Actions (MSCA)
A highly convergent strategy for the synthesis of the natural product (-)-rubriflordilactone B, and the proposed structure of (-)-pseudo-rubriflordilactone B, is described. Late stage coupling of diynes containing the respective natural product FG rings with a common AB ring aldehyde precedes rhodium-catalyzed [2+2+2] alkyne cyclotrimerization to form the natural product skeleton, with the syntheses completed in just one further operation. This work resolves the uncertainty surrounding the identity of pseudo-rubriflordilactone B and provides a robust platform for further synthetic and biological investigations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据