期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 50, 页码 18136-18140出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909971
关键词
[4+1]-annulation; asymmetric catalysis; C-H activation; chiral Cp ligands; rhodium
资金
- Swiss National Science Foundation [157741]
An efficient (CpRhIII)-Rh-x-catalyzed enantioselective alkenyl C-H functionalization/[4+1] annulation of acryl amides and allenes is reported. The described transformation provides straightforward access to enantioenriched alpha,beta-unsaturated-gamma-lactams bearing a quaternary stereocenter. The reaction operates under mild conditions, displays a broad functional-group tolerance, and provides 2H-pyrrol-2-ones with excellent selectivity of up to 97:3 er. Such scaffolds are frequently found in natural products and synthetic bioactive compounds and are of significant synthetic value. It is noteworthy that the allene serves as a one-carbon unit in the [4+1]-annulation.
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