期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 1, 页码 358-363出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201907661
关键词
Alzheimer's disease; biopolymers; nucleic acid; amyloid co-assembly; solid-state NMR spectroscopy
资金
- NSF [CHE-1507932, NSF/DMR-BSF 1610377]
- NIH Alzheimer's Disease Research Center [P50AG025688]
Proteinaceous plaques associated with neurodegenerative diseases contain many biopolymers including the polyanions glycosaminoglycans and nucleic acids. Polyanion-induced amyloid fibrillation has been implicated in disease etiology, but structural models for amyloid/nucleic acid co-assemblies remain limited. Here we constrain nucleic acid/peptide interactions with model peptides that exploit electrostatic complementarity and define a novel amyloid/nucleic acid co-assembly. The structure provides a model for nucleic acid/amyloid co-assembly as well as insight into the energetic determinants involved in templating amyloid assembly.
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