期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 2, 页码 896-902出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201912027
关键词
aggregation; biosensor; DNA; G-quadruplex; logic gate
资金
- Knut and Alice Wallenberg Foundation [KAW2015-0189]
- Swedish Research Council [VR-NT 2017-05235, VR-MH 2018-02651]
- MIMS Excellence by Choice Postdoctoral Programme
- Kempe foundations [SMK-1632]
- National Microscopy Infrastructure [VR-RFI 2016-00968]
The design of turn-on dyes with optical signals sensitive to the formation of supramolecular structures provides fascinating and underexplored opportunities for G-quadruplex (G4) DNA detection and characterization. Here, we show a new switching mechanism that relies on the recognition-driven disaggregation (on-signal) of an ultrabright coumarin-quinazoline conjugate. The synthesized probe selectively lights-up parallel G4 DNA structures via the disassembly of its supramolecular state, demonstrating outputs that are easily integrable into a label-free molecular logic system. Finally, our molecule preferentially stains the G4-rich nucleoli of cancer cells.
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