期刊
BIOCONJUGATE CHEMISTRY
卷 27, 期 4, 页码 1023-1029出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.6b00051
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- Academy of Finland [251539]
- University of Turku
- Turku University Hospital
- Abo Akademi University
- Academy of Finland (AKA) [251539, 251539] Funding Source: Academy of Finland (AKA)
meso-Tris (pyri din-4-yl) (4-carboxyphenyl)porphyrin and 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (Photochlor, HPPH) were amide-coupled to 1R,2S,3R,4R-2,3-dihydroxy-4-(hydromethyl)-1-aminocyclopentane and immobilized via an ester linkage to long chain alkyl amine-derivatized controlled pore glass (LCAA-CPG). The applicability of these supports (5 and 6) for the synthesis of porphyrin conjugates with oligomeric biomolecules was demonstrated using an automated phosphoramidite coupling chemistry. Cleavage from the support with concentrated ammonia gave the products, viz., porphyrin conjugates of oligonucleotides (7-9) and dendritic glycoclusters (10-13) and a cyclooctyne derivative (14) in 23-58% yield. In addition, the synthesized cyclooctyne derivative of meso-tris(pyridin-4-yl)(4-carboxyphenyl)porphyrin (14) was conjugated with an azidopropyl-modified hyaluronic acid-(19). The hyaluronic acid-porphyrin conjugate (15) was radiolabeled with Cu-64 and its (15[Cu-64]) receptor binding affinity to CD44-expressing tumor cells was evaluated.
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