期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 4, 页码 1430-1434出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201912137
关键词
antibiotics; endotoxin; Gram-negative bacteria; gold nanosheets; supramolecular chemistry
资金
- NHRI [NHRI-BN-107-PP-30]
- Ministry of Science and Technology of Taiwan [MOST-106-2113-M-400-005-MY3]
A strong interaction between colistin, a last-resort antibiotic of the polymyxin family, and free lipopolysaccharide (LPS, also referred to as endotoxin), released from the Gram-negative bacterial (GNB) outer membrane (OM), has been identified that can decrease the antibacterial efficacy of colistin, potentially increasing the dose of this antibiotic required for treatment. The competition between LPS in the GNB OM and free LPS for the interaction with colistin was prevented by using a supramolecular trap to capture free LPS. The supramolecular trap, fabricated from a subnanometer gold nanosheet with methyl motifs (SAuM), blocks lipid A, preventing the interaction between lipid A and colistin. This can minimize endotoxemia and maximize the antibacterial efficacy of colistin, enabling colistin to be used at lower doses. Thus, the potential crisis of colistin resistance could be avoided.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据