期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 47, 页码 16869-16872出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201910490
关键词
cofactors; enzymes; nickel; pincer ligands; reaction mechanisms
资金
- Swiss National Science Foundation
A novel nickel pincer cofactor was recently discovered in lactate racemase. Reported here are three synthetic nickel pincer complexes that are both structural and functional models of the pincer cofactor in lactate racemase. DFT computations suggest the ipso-carbon atom of the pyridinium pincer ligands act as a hydride acceptor for lactate isomerization, whereas an organometallic pathway involving nickel-mediated beta-hydride elimination is less favored.
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