期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 47, 页码 16826-16830出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909883
关键词
cancer; drug delivery; fluorescence; nanostructures; theranostics
资金
- National Natural Science Foundation of China [21874043, 21788102, 21672062, 11675251, 21834007]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- National Key R&D Program of China [2016YFA0400900]
- CAS [QYZDJSSW-SLH031]
- Key Research Program of Frontier Sciences
NIR light responsive nanoplatforms hold great promise for on-demand drug release in precision cancer medicine. However, currently available systems utilize always-on photothermal transducers that lack target specificity, and thus inaccurately differentiate tumors from normal tissues. Developed here is a theranostic nanoplatform featuring H2S-mediated in situ production of NIR photothermal agents for imaging-guided and photocontrolled drug release. The system targets H2S-rich cancers. This nanoplatform shows H2S-activatable NIR-II emission and NIR light controllable release of the drug Camptothecin-11. Upon administering the system to HCT116 tumor-bearing mice, the tumor is greatly suppressed with minimal side effects, arising from the synergy of the cancer-specific and NIR light activated therapy. This theranostic nanoplatform thus sheds light on precision medicine with guidance through NIR-II imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据