期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 44, 页码 15752-15756出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909741
关键词
chalcogen bonds; fluorescent probes; force imaging; lipid bilayer membranes; push-pull fluorophores
资金
- University of Geneva
- Swiss National Centre of Competence in Research (NCCR) Chemical Biology
- NCCR Molecular Systems Engineering
- Swiss NSF
- National Institutes of Health [P41-GM104601]
- XSEDE [MCA06N060]
Planarizable push-pull probes have been introduced to demonstrate physical forces in biology. However, the donors and acceptors needed to polarize mechanically planarized probes are incompatible with their twisted resting state. The objective of this study was to overcome this flipper dilemma with chalcogen-bonding cascade switches that turn on donors and acceptors only in response to mechanical planarization of the probe. This concept is explored by molecular dynamics simulations as well as chemical double-mutant cycle analysis. Cascade switched flipper probes turn out to excel with chemical stability, red shifts adding up to high significance, and focused mechanosensitivity. Most important, however, is the introduction of a new, general and fundamental concept that operates with non-trivial supramolecular chemistry, solves an important practical problem and opens a wide chemical space.
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