期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 45, 页码 16177-16180出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909700
关键词
amino alcohols; chiral resolution; kinetic resolution; organotin complexes
资金
- National Natural Science Foundation of China [21772086]
- Natural Science Foundation of Jiangsu Province [BK20181254]
A highly efficient kinetic resolution of racemic amino alcohols has been achieved for the first time with a chiral tin catalyst. A chiral organotin compound with 3,4,5-trifluorophenyl groups at the 3,3 '-positions of the binaphthyl framework enabled this transformation with excellent yield and high enantioselectivity. The process tolerates aryl- and alkyl-substituted amino alcohols and a variety of other substrates, affording the corresponding products in high enantioselectivity and with s factors up to >500.
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