期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 45, 页码 16067-16070出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201908950
关键词
biosensors; fluorescent probes; hydrogen sulfide; imaging agents; S-nitrosothiols
资金
- NIH [R01GM125968]
- NSF [CHE1738305]
- Ministry of Education, Sciences, Sports and Technology (MEXT), Japan [18H05277, 19K07554]
- Grants-in-Aid for Scientific Research [19K07554, 18H05277] Funding Source: KAKEN
Thionitrous acid (HSNO), the smallest S-nitrosothiol, is emerging as a potential key intermediate in cellular redox regulation linking two signaling molecules H2S and NO. However, the chemical biology of HSNO remains poorly understood. A major hurdle is the lack of methods for selective detection of HSNO in biological systems. Herein, we report the rational design, synthesis, and evaluation of the first fluorescent probe TAP-1 for HSNO detection. TAP-1 showed high selectivity and sensitivity to HSNO in aqueous media and cells, providing a useful tool for understanding the functions of HSNO in biology.
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