期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 46, 页码 16523-16527出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201910865
关键词
Ag@LDH; biomarkers; gas phase diffusion; microarray SERS sensors; SERS
资金
- National Natural Science Foundation of China [21635002, 21621062, 201874005]
- National Key Research and Development Program of China [2018YFA0208800]
To detect biomarkers from human exhalation, air flow dynamics on the nanoparticle surface were explored by a surface-enhanced Raman scattering (SERS) sensor. A hollow Co-Ni layered double hydroxide (LDH) nanocage on Ag nanowires (Ag@LDH) was prepared. Ag nanowires provided amplified Raman signals for trace determination; hollow LDH nanocages served as the gaseous confinement cavity to improve capture and adsorption of gaseous analytes. The Raman intensity and logarithmic analyte concentration exhibit an approximately linear relationship; the detection limit of SERS sensors for aldehyde is 1.9x10(-9) v/v (1.9 ppb). Various aldehydes in mixed mimetic gas are distinguished by Raman spectra statistical analysis assisted by multivariate methods, including principal component analysis and hierarchical cluster analysis. The information was recorded in a barcode, which can be used for the design and development of a desktop SERS sensor analysis system for large-scale lung cancer detection.
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