期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 45, 页码 16115-16118出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909922
关键词
electrochemistry; electrosynthesis; green chemistry; lactones; radical cyclisation
资金
- Engineering and Physical Sciences Research Council [EP/S017097/1]
- University of Greenwich
- University Alliance Applied Biosciences for Health Doctoral Training Alliance
- EPSRC [EP/S017097/1] Funding Source: UKRI
A new electrochemical methodology has been developed for the generation of oxycarbonyl radicals under mild and green conditions from readily available hemioxalate salts. Mono- and multi-functionalised gamma-butyrolactones were synthesised through exo-cyclisation of these oxycarbonyl radicals with an alkene, followed by the sp(3)-sp(3) capture of the newly formed carbon-centred radical. The synthesis of functionalised valerolactone derivatives was also achieved, demonstrating the versatility of the newly developed methodology. This represents a viable synthetic route towards pharmaceutically important fragments and further demonstrates the practicality of electrosynthesis as a green and economical method to activate small organic molecules.
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