期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 7, 页码 2618-2622出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201908951
关键词
bicyclo[1.1.0]butanes; cyclobutanes; late-stage functionalization; photocatalysis; strained molecules
资金
- CEA
A new photoredox-catalyzed decarboxylative radical addition approach to functionalized cyclobutanes is described. The reaction involves an unprecedented formal Giese-type addition of C(sp(3))-centered radicals to highly strained bicyclo[1.1.0]butanes. The mild photoredox conditions, which make use of a readily available and bench stable phenyl sulfonyl bicyclo[1.1.0]butane, proved to be amenable to a diverse range of alpha-amino and alpha-oxy carboxylic acids, providing a concise route to 1,3-disubstituted cyclobutanes. Furthermore, kinetic studies and DFT calculations unveiled mechanistic details on bicyclo[1.1.0]butane reactivity relative to the corresponding olefin system.
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