期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 40, 页码 14224-14228出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909345
关键词
cancer therapy; DNA nanotechnology; drug delivery; nanobody; platinum
资金
- National Natural Science Foundation of China [21573051, 21708004, 21721002, 91543101]
- National Basic Research Program of China [2016YFA0201601, 2018YFA0208900]
- Beijing Municipal Science AMP
- Technology Commission [Z161100000116036]
- Key Research Program of Frontier Sciences, CAS [QYZDB-SSW-SLH029]
- CAS Interdisciplinary Innovation Team
- K. C. Wong Education Foundation
- Youth Innovation Promotion Association of CAS [2017051]
The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum-based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double-bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA-based platinum-drug delivery system provides a promising strategy for the treatment of tumors.
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