期刊
AMERICAN JOURNAL OF NEURORADIOLOGY
卷 40, 期 12, 页码 2073-2080出版社
AMER SOC NEURORADIOLOGY
DOI: 10.3174/ajnr.A6295
关键词
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资金
- National Institutes of Health [P41 EB015896, R01 EB020613, UL 1TR002541]
- Radiological Society of North America Research Resident Grant
- Siemens Healthineers
- Harvard Catalyst, Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health) [UL 1TR002541]
- Harvard University
BACKGROUND AND PURPOSE: SWI is valuable for characterization of intracranial hemorrhage and mineralization but has long acquisition times. We compared a highly accelerated wave?controlled aliasing in parallel imaging (CAIPI) SWI sequence with 2 commonly used alternatives, standard SWI and T2*-weighted gradient recalled-echo (T2*W GRE), for routine clinical brain imaging at 3T. MATERIALS AND METHODS: A total of 246 consecutive adult patients were prospectively evaluated using a conventional SWI or T2*W GRE sequence and an optimized wave?CAIPI SWI sequence, which was 3?5 times faster than the standard sequence. Two blinded radiologists scored each sequence for the presence of hemorrhage, the number of microhemorrhages, and severity of motion artifacts. Wave?CAIPI SWI was then evaluated in head-to-head comparison with the conventional sequences for visualization of pathology, artifacts, and overall diagnostic quality. Forced-choice comparisons were used for all scores. Wave?CAIPI SWI was tested for superiority relative to T2*W GRE and for noninferiority relative to standard SWI using a 15% noninferiority margin. RESULTS: Compared with T2*W GRE, wave?CAIPI SWI detected hemorrhages in more cases (P?
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