期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1865, 期 2, 页码 190-203出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2016.02.003
关键词
Cell cycle progression; Mitotic kinase; Mitosis; Polo-like kinase-1; Tumorigenesis
资金
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology [NRF-2013R1A1A2008541]
- Hallym University research fund [HRF-G-2015-3]
- National Research Foundation of Korea [2013R1A1A2008541] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
PLK-1 is a key player in the eukaryotic cell cycle. Cell cycle progression is precisely controlled by cell cycle regulatory kinases. PLK-1 is a mitotic kinase that actively regulates the G2/M transition, mitosis, mitotic exit, and cytokinesis. During cell cycle progression, PLK-1 controls various events related to the cell cycle maturation, directly and/or indirectly. On the contrary, aberrant expression of PLK-1 is strongly associated with tumorigenesis and its poor prognosis. The misexpression of PLK-1 causes the abnormalities including aneuploidy, mitotic defects, leading to tumorigenesis through inhibiting the p53 and pRB genes. Therefore, we reviewed the role of PLK-1 in the cell cycle progression and in the tumorigenesis either as a cell cycle regulator or on an attractive anti-cancer drug target. (C) 2016 Published by Elsevier B.V.
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