4.5 Review

De novo peroxisome biogenesis: Evolving concepts and conundrums

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出版社

ELSEVIER
DOI: 10.1016/j.bbamcr.2015.09.014

关键词

De novo peroxisome biogenesis; Role of endoplasmic reticulum in peroxisome biogenesis, peroxisomal membrane protein biogenesis; Role of the endoplasmic reticulum in yeast, mammals and plants; Intra-ER sorting, import of PMPs into the ER, growth and division vs de novo peroxisome biogenesis; Pre-peroxisomal vesicles, ppVs; Pre-peroxisomal-ER, pER

资金

  1. NIH [RO1DK41737]

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Peroxisomes proliferate by growth and division of pre-existing peroxisomes or could arise de novo. Though the de novo pathway of peroxisome biogenesis is a more recent discovery, several studies have highlighted key mechanistic details of the pathway. The endoplasmic reticulum (ER) is the primary source of lipids and proteins for the newly-formed peroxisomes. More recently, an intricate sorting process functioning at the ER has been proposed, that segregates specific PMPs first to peroxisome-specific ER domains (pER) and then assembles PMPs selectively into distinct pre-peroxisomal vesicles (ppVs) that later fuse to form import-competent peroxisomes. In addition, plausible roles of the three key peroxins Pex3, Pex16 and Pex19, which are also central to the growth and division pathway, have been suggested in the de novo process. In this review, we discuss key developments and highlight the unexplored avenues in de novo peroxisome biogenesis. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. (C) 2015 Elsevier B.V. All rights reserved.

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