期刊
AGING-US
卷 11, 期 20, 页码 8998-9012出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.102366
关键词
platelet; RNA; biomarker; colorectal cancer; TIMP1
资金
- National Natural Science Foundation of China [81602145]
- Jiangsu Provincial Natural Science Foundation [BK20171509]
- Jiangsu Provincial Medical Youth Talent, The Project of Invigorating Health Care through Science, Technology Education [QNRC2016649]
- China Postdoctoral Science Foundation [2018M632265]
- The Talents Program of Jiangsu Cancer Hospital [2017-33]
Platelets have been shown to promote the growth of tumors, including colorectal cancer. The RNA profile of tumor-educated platelets has the possibility for cancer diagnosis. We used RNA sequencing to identified the gene expression signature in platelets from colorectal cancer patients and healthy volunteers. We then verified the selected biomarkers from the RNA sequencing in a two-step case-control study using quantitative reverse-transcription polymerase chain reaction. We found that TIMP1 mRNA levels are higher in platelets from colorectal cancer patients than in platelets from healthy volunteers and patients with inflammatory bowel diseases. Additionally, TIMP1 mRNA expressed in platelets from colorectal cancer patients can be carried into colorectal cancer cells, where it promotes tumor growth in vivo and in vitro. These findings show that the TIMP1 mRNA in platelets is a potential independent diagnostic biomarker for colorectal cancer, and that platelets can carry RNAs into colorectal cancer cells to promote colorectal cancer development.
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