期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1863, 期 6, 页码 1379-1384出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2016.01.014
关键词
NAADP; Ryanodine receptor; T cell; Signal transduction
资金
- Deutsche Forschungsgemeinschaft [GU 360/15-1, 360/16-1]
- Forschungszentrum Medizintechnik Hamburg
- Forderfonds Medizin (FFM) of the University Medical Center Hamburg-Eppendorf [NWF 15/13]
- Hertie Foundation [P1140086]
- Landesforschungs-Forderung of the City of Hamburg (Research Group ReAd Me)
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca2+ mobilizing second messenger that belongs to the superfamily of regulatory adenine nucleotides. Though NAADP has been known since 20 years, several aspects of its metabolism and molecular mode of action are still under discussion. Though the importance of the type 1 ryanodine receptor was discovered and published already in 2002 Hohenegger et al. (2002 Oct 15), recent data re-emphasize these original findings in pancreatic acinar cells and in T-lymphocytes. Here we review recent developments in NAADP formation and metabolism, putative target Ca2+ channels for NAADP with special emphasis on the type 1 ryanodine receptor, and NAADP binding proteins. The latter are basis for a unifying hypothesis for NAADP action. Finally, the role of NAADP in T cell Ca2+ signaling and activation is discussed. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen. (C) 2016 Elsevier B.V. All rights reserved.
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