期刊
AGING CELL
卷 19, 期 1, 页码 -出版社
WILEY
DOI: 10.1111/acel.13038
关键词
adiponectin; aging; calorie restriction; GDF11; heterochronic parabiosis; rejuvenation
资金
- Agence Nationale de Recherche [ANR-10-LABX-73, ANR-11-IDEX-0004-02, ANR-15-CE37-0004-01]
- Morrison Trust Foundation
- Barshop Institute Nathan Shock Center
- Agence Nationale de la Recherche (ANR) [ANR-15-CE37-0004] Funding Source: Agence Nationale de la Recherche (ANR)
Aging is a negative regulator of general homeostasis, tissue function, and regeneration. Changes in organismal energy levels and physiology, through systemic manipulations such as calorie restriction and young blood infusion, can regenerate tissue activity and increase lifespan in aged mice. However, whether these two systemic manipulations could be linked has never been investigated. Here, we report that systemic GDF11 triggers a calorie restriction-like phenotype without affecting appetite or GDF15 levels in the blood, restores the insulin/IGF-1 signaling pathway, and stimulates adiponectin secretion from white adipose tissue by direct action on adipocytes, while repairing neurogenesis in the aged brain. These findings suggest that GDF11 has a pleiotropic effect on an organismal level and that it could be a linking mechanism of rejuvenation between heterochronic parabiosis and calorie restriction. As such, GDF11 could be considered as an important therapeutic candidate for age-related neurodegenerative and metabolic disorders.
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