期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1863, 期 2, 页码 219-228出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2015.11.002
关键词
LIM-only protein FHL2; Protein-protein interactions; Signaling pathways; Cardiovascular function
资金
- BioMedical Materials Institute [P1.02 NEXTREAM]
- Netherlands CardioVascular Research Initiative: Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organization for Health Research and Development and the Royal Netherlands Academy of Sciences [CVON2011-19]
- Rembrandt Institute Cardiovascular Sciences, the Netherlands (RICS-deVries/Versteeg)
- Dutch Ministry of Economic Affairs
- Dutch Heart Foundation
FHL2 belongs to the LIM-domain only proteins and contains four and a half LIM domains, each of which are composed of two zinc finger structures. FHL2 exhibits specific interaction with proteins exhibiting diverse functions, including transmembrane receptors, transcription factors and transcription co-regulators, enzymes, and structural proteins. The function of these proteins is regulated by FHL2, which modulates intracellular signal transduction pathways involved in a plethora of cellular tasks. The present review summarizes the current knowledge on the protein interactome of FHL2 and provides an overview of the functional implication of these interactions in apoptosis, migration, and regulation of nuclear receptor function. FHL2 was originally identified in the heart and there is extensive literature available on the role of FHL2 in the cardiovascular system, which is also summarized in this review. (C) 2015 Elsevier B.V. All rights reserved.
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