期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 1, 页码 224-229出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901321
关键词
Spirocyclization; DABSO; Sulfur dioxide; Sulfones; diazonium salts
资金
- Department of Science and Technology, India [DST/TMD/SERI/S111(G)]
- SK would like DST India
- UGC India
Herein, we report an efficient synthesis of azaspiro[4,5]-decanes and azaspiro[4,5]-trienones by the radical cascade spirocyclization of N-benzylacrylamides or N-arylpropiolamides respectively. These reactions proceed under metal free conditions and involve in situ generation of aryl sulfonyl radicals from DABSO and aryl diazonium salts. Furthermore, a catalyst free visible light mediated protocol was developed for the sulfonylative spirocyclization of N-aryl alkynamides using diaryliodonium salts. The utility of these protocols were justified by the excellent compatability of a wide range of functional groups, good yields and scalablity under mild conditions at room temperature.
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