期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 2, 页码 320-325出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901187
关键词
C-O cross-coupling; telescoping; hypervalent iodine; diaryliodonium; diaryl ether
资金
- Portland State University
Herein, we describe a synthetic approach for arylation that exploits the in situ formation and reaction of an unsymmetrical diaryliodonium salt. In this way, aryl iodides are used as reagents in a metal-free reaction with phenols, and a trimethoxyphenyl (TMP) group is used as a dummy group to facilitate transfer of a wide range of aryl moieties. The scope of aryl electrophiles and phenol nucleophiles is broad (>30 examples) and the yields are high (52-95%, 80% avg.). One-pot coupling reactions avoid the synthesis of diaryliodonium salts and provide opportunities for sequential reactions and novel chemoselectivity.
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