期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 1, 页码 126-132出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901136
关键词
C-O coupling; Palladium; Carboxylic acid; Aryl Iodides; Ligand-controlled C-O Bond Coupling of Carboxylic Acids and Aryl Iodides; Experimental and Computational Insights
资金
- National Natural Science Foundation of China [21801011, 21825101]
- Shenzhen Basic Research Program [JCYJ20170818085510474, JCYJ20170818085438996, JCYJ20170412150343516]
Palladium-catalyzed cross-coupling reactions between carboxylic acids and aryl halides have several possible competitive pathways. Decarboxylative C-C bond coupling and C-H arylation are well established in the literature. However, direct C-O bond coupling between carboxylic acids and aryl halides has received little success. In this report, we describe a protocol for exclusive C-O bond formation, enabled by a bidentate N,N-ligand such as 1,10-phenanthroline. The reaction is general for a broad range of carboxylic acids and iodoarenes. Experimental evidence and computational results suggest a high energy barrier for the alternative pathway of decarboxylative carbon-carbon bond coupling.
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