期刊
ADVANCED MATERIALS
卷 31, 期 52, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201904894
关键词
cancer theranostics; Cerenkov radiation; multimodal imaging; positron emission tomography; targeted drug delivery
类别
资金
- National Natural Science Foundation of China [81601605, 21571147]
- Postdoctoral Science Foundation of China [2016M600670]
- Natural Science Foundation of SZU [827-000143]
- Shenzhen Peacock Plan [KQTD2016053112051497]
- Shenzhen Basic Research Program [JCYJ20170302151858466]
- University of Wisconsin-Madison
- National Institutes of Health [P30CA014520]
- Brazilian Science without Borders Program (SwB-CNPq)
Cerenkov radiation (CR) from radionuclides can act as a built-in light source for cancer theranostics, opening a new horizon in biomedical applications. However, considerably low tumor-targeting efficiency of existing radionuclides and radionuclide-based nanomedicines limits the efficacy of CR-induced theranostics (CRIT). It remains a challenge to precisely and efficiently supply CR energy to the tumor site. Here, a missile-detonation strategy is reported, in which a high dose of p-SCN-Bn-deferoxamine-porphyrin-PEG nanocomplex (Df-PPN) is first adminstered as a CR energy receiver/missile to passively target to tumor, and then a low dose of the Zr-89-labeled Df-PPN is administrated as a CR energy donor/detonator, which can be visualized and quantified by Cerenkov energy transfer imaging, positron-emission tomography, and fluorescence imaging. Based on homologous properties, the colocalization of Df-PPN and Zr-89-Df-PPN in the tumor site is maximized and efficient CR energy transfer is enabled, which maximizes the tumor-targeted CRIT efficacy in an optimal spatiotemporal setting while also reducing adverse off-target effects from CRIT. This precise and efficient CRIT strategy causes significant tumor vascular damage and inhibited tumor growth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据