期刊
ADVANCED MATERIALS
卷 31, 期 52, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201904914
关键词
aggregation-induced emission; cancer immunotherapy; immunogenic cell death inducer; mitochondrial targeting; photosensitizers
类别
资金
- NSFC [51622305, 51873092]
- National Basic Research Program of China [2015CB856503]
- Fundamental Research Funds for the Central Universities, Nankai University [63191521, 63171218, 63191176]
- Fundamental Research Funds for the Central Universities, Nankai University, the Science and Technology Support Program of Tianjin [16YFZCSY01020]
Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer-based ones can hardly induce sufficient ICD to achieve satisfactory cancer immunotherapy by themselves. Herein, an organic photosensitizer (named TPE-DPA-TCyP) with a twisted molecular structure, strong aggregation-induced emission activity, and specific ability is reported for effectively inducing focused mitochondrial oxidative stress of cancer cells, which can serve as a much superior ICD inducer to the popularly used ones, including chlorin e6 (Ce6), pheophorbide A, and oxaliplatin. Furthermore, more effective in vivo ICD immunogenicity of TPE-DPA-TCyP than Ce6 is also demonstrated using a prophylactic tumor vaccination model. The underlying mechanism of the effectiveness and robustness of TPE-DPA-TCyP in inducing antitumor immunity and immune-memory effect in vivo is verified by immune cell analyses. This study thus reveals that inducing focused mitochondrial oxidative stress is a highly effective strategy to evoke abundant and large-scale ICD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据