期刊
ADVANCED MATERIALS
卷 31, 期 49, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201905087
关键词
cancer; long-lasting luminescence; passive targeting; X-rays; ZnGa2O4; Cr
类别
资金
- Ministry of Science and Technology, Taiwan [MOST106-2314-B-182A-008-MY3, MOST107-2113-M-006-004-MY2]
- Chang Gung Medical Foundation [CMRPG8I0141-3]
- Center of Applied Nanomedicine, National Cheng Kung University, under the Featured Areas Research Center Program
Chromium-doped zinc gallate, ZnGa2O4:Cr3+ (ZGC), is viewed as a long-lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere-like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well-defined cubic feature in nanoscale. The process by which dispersed and well-defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X-ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X-rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X-ray excitation is sufficient for imaging of deep-seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors.
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