期刊
ADVANCED MATERIALS
卷 31, 期 46, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201904607
关键词
bioactive nanoparticles; cyclodextrin; inflammation; macrophages; neutrophils
类别
资金
- National Natural Science Foundation of China [81801841, 81971727] Funding Source: Medline
- Postdoctoral Science Foundation of China [2018M643863] Funding Source: Medline
- Program for Distinguished Young Scholars of TMMU Funding Source: Medline
- Chongqing Special Postdoctoral Science Foundation [XmT2018067] Funding Source: Medline
- Innovation Program for Key Technologies of Southwest Hospital [SWH2016ZDCX1016] Funding Source: Medline
Inflammation is a common cause of many acute and chronic inflammatory diseases. A major limitation of existing anti-inflammatory therapeutics is that they cannot simultaneously regulate pro-inflammatory cytokine production, oxidative stress, and recruitment of neutrophils and macrophages. To overcome this limitation, nanoparticles (NPs) with multiple pharmacological activities are synthesized, using a chemically modified cyclic oligosaccharide. The manufacture of this type of bioactive, saccharide material-based NPs (defined as LCD NP) is straightforward, cost-effective, and scalable. Functionally, LCD NP effectively inhibits inflammatory response, oxidative stress, and cell migration for both neutrophils and macrophages, two major players of inflammation. Therapeutically, LCD NP shows desirable efficacies for the treatment of acute and chronic inflammatory diseases in mouse models of peritonitis, acute lung injury, and atherosclerosis. Mechanistically, the therapeutic benefits of LCD NP are achieved by inhibiting neutrophil-mediated inflammatory macrophage recruitment and by preventing subsequent pro-inflammatory events. In addition, LCD NP shows good safety profile in a mouse model. Thus, LCD NP can serve as an effective anti-inflammatory nanotherapy for the treatment of inflammatory diseases mainly associated with neutrophil and macrophage infiltration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据