期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201907716
关键词
chemodynamic therapy; Fenton-like reaction; in situ polymerization; mesoporous organosilica; ultrasmall gold nanoparticle
类别
资金
- Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- National Natural Science Foundation of China [91859207, 81771873, 81471689]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [ZIAEB000073] Funding Source: NIH RePORTER
The combination of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic therapy (CDT) holds great promise for enhancing ROS-mediated cancer treatment. Herein, an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor is reported to integrate the synergistic effect of PDT/CDT for enhancing ROS-mediated pancreatic ductal adenocarcinoma treatment. 2-(1-hexyloxyethyl)-2-devinylpyropheophorbide-a photosensitizer is hybridized within the framework of HMON via an in situ framework growth approach. Then, the hollow cavity of HMONs is exploited as a nanoreactor for in situ polymerization to synthesize the polymer containing thiol groups, thereby enabling the immobilization of ultrasmall gold nanoparticles, which behave like glucose oxidase-like nanozyme, converting glucose into H2O2 to provide self-supplied H2O2 for CDT. Meanwhile, Cu2+-tannic acid complexes are further deposited on the surface of HMONs (HMON-Au@Cu-TA) to initiate Fenton-like reaction to covert the self-supplied H2O2 into center dot OH, a highly toxic ROS. Finally, collagenase (Col), which can degrade the collagen I fiber in the extracellular matrix, is loaded into HMON-Au@Cu-TA to enhance the penetration of HMONs and O-2 infiltration for enhanced PDT. This study provides a good paradigm for enhancing ROS-mediated antitumor efficacy. Meanwhile, this research offers a new method to broaden the application of silica based nanotheranostics.
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