相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing
Zhen Zhang et al.
MACROMOLECULAR RAPID COMMUNICATIONS (2019)
Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects
Feng Qi et al.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING (2019)
Gene editing for inflammatory disorders
David T. Ewart et al.
ANNALS OF THE RHEUMATIC DISEASES (2019)
Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing
Xiaoti Yang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9
Hong-Xia Zhang et al.
MOLECULAR THERAPY (2019)
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
Christopher E. Nelson et al.
NATURE MEDICINE (2019)
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Yuxuan Wu et al.
NATURE MEDICINE (2019)
Identification of preexisting adaptive immunity to Cas9 proteins in humans
Carsten T. Charlesworth et al.
NATURE MEDICINE (2019)
In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease
Hanseul Park et al.
NATURE NEUROSCIENCE (2019)
Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids
Tobias Killian et al.
NUCLEIC ACIDS RESEARCH (2019)
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
Yuhong Cao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Development of CLAN Nanomedicine for Nucleic Acid Therapeutics
Cong-Fei Xu et al.
SMALL (2019)
Engineering of high-precision base editors for site-specific single nucleotide replacement
Junjie Tan et al.
NATURE COMMUNICATIONS (2019)
Lecithin nano-liposomal particle as a CRISPR/Cas9 complex delivery system for treating type 2 diabetes
Eun Yi Cho et al.
JOURNAL OF NANOBIOTECHNOLOGY (2019)
Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing
Danny Wilbie et al.
ACCOUNTS OF CHEMICAL RESEARCH (2019)
Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations
Reza Shahbazi et al.
NATURE MATERIALS (2019)
Gene correction for SCID-X1 in long-term hematopoietic stem cells (vol 10, 1634, 2019)
Mara Pavel-Dinu et al.
NATURE COMMUNICATIONS (2019)
CRISPR/Cas9 Delivery Mediated with Hydroxyl-Rich Nanosystems for Gene Editing in Aorta
Xiaoping Zhang et al.
ADVANCED SCIENCE (2019)
Near-infrared upconversion-activated CRISPR-Cas9 system: A remote-controlled gene editing platform
Yongchun Pan et al.
SCIENCE ADVANCES (2019)
Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles
Ji Liu et al.
ADVANCED MATERIALS (2019)
Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer
Man Li et al.
JOURNAL OF CONTROLLED RELEASE (2019)
The clinical application of gene editing: ethical and social issues
Kelly E. Ormond et al.
PERSONALIZED MEDICINE (2019)
Therapeutic potential of CRISPR/Cas9 gene editing in engineered T-cell therapy
Qianqian Gao et al.
CANCER MEDICINE (2019)
A boronic acid-rich dendrimer with robust and unprecedented efficiency for cytosolic protein delivery and CRISPR-Cas9 gene editing
Chongyi Liu et al.
SCIENCE ADVANCES (2019)
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Guojun Chen et al.
NATURE NANOTECHNOLOGY (2019)
Therapeutic genome editing of triple-negative breast tumors using a noncationic and deformable nanolipogel
Peng Guo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Gene Editing: Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein (Small 38/2019)
Ran Chen et al.
Small (2019)
Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles
Yamin Li et al.
BIOMATERIALS SCIENCE (2019)
In situ repurposing of dendritic cells with CRISPR/Cas9-based nanomedicine to induce transplant tolerance
Yue Zhang et al.
BIOMATERIALS (2019)
Delivery of CRISPR/Cas9 by Novel Strategies for Gene Therapy
Le Wang et al.
CHEMBIOCHEM (2019)
Material solutions for delivery of CRISPR/Cas-based genome editing tools: Current status and future outlook
Tao Wan et al.
MATERIALS TODAY (2019)
Gesicle-Mediated Delivery of CRISPR/Cas9 Ribonucleoprotein Complex for Inactivating the HIV Provirus
Lee A. Campbell et al.
MOLECULAR THERAPY (2019)
In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9
Zhelong Li et al.
NANO LETTERS (2019)
CRISPR-Cas: a tool for cancer research and therapeutics
Hao Yin et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
Multistage Delivery Nanoparticle Facilitates Efficient CRISPR/dCas9 Activation and Tumor Growth Suppression In Vivo
Qi Liu et al.
ADVANCED SCIENCE (2019)
Spatial control of in vivo CRISPR-Cas9 genome editing via nanomagnets
Haibao Zhu et al.
NATURE BIOMEDICAL ENGINEERING (2019)
Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis
Romain Rouet et al.
ACS CHEMICAL BIOLOGY (2019)
DNAzyme activated protein-scaffolded CRISPR-Cas9 nanoassembly for genome editing
Xueli Zhu et al.
CHEMICAL COMMUNICATIONS (2019)
Biomaterials as vectors for the delivery of CRISPR-Cas9
Joon Eoh et al.
BIOMATERIALS SCIENCE (2019)
Cytosolic delivery of CRISPR/Cas9 ribonucleoproteins for genome editing using chitosan-coated red fluorescent protein
Jie Qiao et al.
CHEMICAL COMMUNICATIONS (2019)
Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework
Shahad K. Alsaiari et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles
Ying-Li Luo et al.
ACS NANO (2018)
Simple in Vivo Gene Editing via Direct Self-Assembly of Cas9 Ribonucleoprotein Complexes for Cancer Treatment
Seung Mm Kim et al.
ACS NANO (2018)
Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems
Masatoshi Maeki et al.
ADVANCED DRUG DELIVERY REVIEWS (2018)
Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy
Peng Wang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Enhanced Cytosolic Delivery and Release of CRISPR/Cas9 by Black Phosphorus Nanosheets for Genome Editing
Wenhua Zhou et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Active Intracellular Delivery of a Cas9/sgRNA Complex Using Ultrasound-Propelled Nanomotors
Malthe Hansen-Bruhn et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
CRISPRed Macrophages for Cell-Based Cancer Immunotherapy
Moumita Ray et al.
BIOCONJUGATE CHEMISTRY (2018)
Optimization of lipid-assisted nanoparticle for disturbing neutrophils-related inflammation
Yang Liu et al.
BIOMATERIALS (2018)
Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities
Ling Li et al.
BIOMATERIALS (2018)
Delivering CRISPR: a review of the challenges and approaches
Christopher A. Lino et al.
DRUG DELIVERY (2018)
Gene editing of MPS I human fibroblasts by co-delivery of a CRISPR/Cas9 plasmid and a donor oligonucleotide using nanoemulsions as nonviral carriers
Roselena Silvestri Schuh et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)
In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9
Zhi-Yao He et al.
HUMAN GENE THERAPY (2018)
History of CRISPR-Cas from Encounter with a Mysterious Repeated Sequence to Genome Editing Technology
Yoshizumi Ishino et al.
JOURNAL OF BACTERIOLOGY (2018)
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing
Romain Rouet et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Efficient gene editing via non-viral delivery of CRISPR-Cas9 system using polymeric and hybrid microcarriers
Alexander S. Timin et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)
Effective PEI-mediated delivery of CRISPR-Cas9 complex for targeted gene therapy
Nari Ryu et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)
Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing
Huahua Yue et al.
NANOSCALE (2018)
Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide
Hong-Xia Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
ARMMs as a versatile platform for intracellular delivery of macromolecules
Qiyu Wang et al.
NATURE COMMUNICATIONS (2018)
Efficient RNA drug delivery using red blood cell extracellular vesicles
Waqas Muhammad Usman et al.
NATURE COMMUNICATIONS (2018)
The CRISPR tool kit for genome editing and beyond
Mazhar Adli
NATURE COMMUNICATIONS (2018)
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
Jonathan D. Finn et al.
CELL REPORTS (2018)
Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs
Yao Lin et al.
ADVANCED SCIENCE (2018)
HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Natronobacterium gregoryi Argonaute
Yeh-Hsing Lao et al.
ADVANCED SCIENCE (2018)
Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours
Bumwhee Lee et al.
NATURE BIOMEDICAL ENGINEERING (2018)
Harnessing CRISPR to combat human viral infections
Hendrik de Buhr et al.
CURRENT OPINION IN IMMUNOLOGY (2018)
CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure
Yuefei Shen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy
Da Zhu et al.
MOLECULAR THERAPY (2018)
Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention
Min Li et al.
NANO RESEARCH (2018)
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
Johnny H. Hu et al.
NATURE (2018)
Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain
Giulia Palermo et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2018)
CRISPR-Cas guides the future of genetic engineering
Gavin J. Knott et al.
SCIENCE (2018)
Fluorinated Acid-Labile Branched Hydroxyl-Rich Nanosystems for Flexible and Robust Delivery of Plasmids
Yu Qi et al.
SMALL (2018)
Cas9 immunity creates challenges for CRISPR gene editing therapies
Julie M. Crudele et al.
NATURE COMMUNICATIONS (2018)
Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Therapeutics
Brittany E. Givens et al.
AAPS JOURNAL (2018)
Nonviral Genome Editing Based on a Polymer-Derivatized CRISPR Nanocomplex for Targeting Bacterial Pathogens and Antibiotic Resistance (vol 28, 957967, 2017)
Yoo Kyung Kang et al.
BIOCONJUGATE CHEMISTRY (2018)
Tumor targeted genome editing mediated by a multi-functional gene vector for regulating cell behaviors
Bo-Ya Liu et al.
JOURNAL OF CONTROLLED RELEASE (2018)
Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
Congfei Xu et al.
NATURE COMMUNICATIONS (2018)
Debugging the genetic code: Non-viral in vivo delivery of therapeutic genome editing technologies
Alexandra S. Piotrowski-Daspit et al.
CURRENT OPINION IN BIOMEDICAL ENGINEERING (2018)
Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice
Ling Li et al.
ACS NANO (2017)
Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
Jason B. Miller et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Poly-sgRNA/siRNA ribonucleoprotein nanoparticles for targeted gene disruption
Jong Seong Ha et al.
JOURNAL OF CONTROLLED RELEASE (2017)
Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting
Seung Min Kim et al.
JOURNAL OF CONTROLLED RELEASE (2017)
Genome editing via delivery of Cas9 ribonucleoprotein
Mark A. DeWitt et al.
METHODS (2017)
CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons
Pierre Billon et al.
MOLECULAR CELL (2017)
RNA targeting with CRISPR-Cas13
Omar O. Abudayyeh et al.
NATURE (2017)
Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage
Nicole M. Gaudelli et al.
NATURE (2017)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin et al.
NATURE BIOTECHNOLOGY (2017)
CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations
Cem Kuscu et al.
NATURE METHODS (2017)
Delivery technologies for genome editing
Hao Yin et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Efficient in vivo gene editing using ribonucleoproteins in skin stem cells of recessive dystrophic epidermolysis bullosa mouse model
Wenbo Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Ex vivo and in vivo genome editing: a regulatory scientific framework from early development to clinical implementation
Houria Bachtarzi
REGENERATIVE MEDICINE (2017)
Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition
Irene Lostale-Seijo et al.
CHEMICAL SCIENCE (2017)
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein
Yong Lei et al.
NATURE COMMUNICATIONS (2017)
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
Eunji Kim et al.
NATURE COMMUNICATIONS (2017)
Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9
Peiwu Qin et al.
NATURE COMMUNICATIONS (2017)
Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
Deborah Y. Kwon et al.
NATURE COMMUNICATIONS (2017)
Genome Editing for Cancer Therapy: Delivery of Cas9 Protein/sgRNA Plasmid via a Gold Nanocluster/Lipid Core-Shell Nanocarrier
Peng Wang et al.
ADVANCED SCIENCE (2017)
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
Kunwoo Lee et al.
NATURE BIOMEDICAL ENGINEERING (2017)
Targeted Delivery of CRISPR/Cas9-Mediated Cancer Gene Therapy via Liposome-Templated Hydrogel Nanoparticles
Zeming Chen et al.
ADVANCED FUNCTIONAL MATERIALS (2017)
Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma
Chao Liang et al.
BIOMATERIALS (2017)
Purified Cas9 Fusion Proteins for Advanced Genome Manipulation
Jovan Mircetic et al.
SMALL METHODS (2017)
The changing landscape of gene editing in hematopoietic stem cells: a step towards Cas9 clinical translation
Daniel P. Dever et al.
CURRENT OPINION IN HEMATOLOGY (2017)
Green Transfection: Cationic Lipid Nanocarrier System Derivatized from Vegetable Fat, Palmstearin Enhances Nucleic Acid Transfections
Priya Dharmalingam et al.
ACS OMEGA (2017)
Lipid nanoparticle-mediated efficient delivery of CRISPR/Cas9 for tumor therapy
Lingmin Zhang et al.
NPG ASIA MATERIALS (2017)
CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery
Hong-Xia Wang et al.
CHEMICAL REVIEWS (2017)
Biodegradable Amino-Ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo
Xinfu Zhang et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges
Rubul Mout et al.
BIOCONJUGATE CHEMISTRY (2017)
Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing
Rubul Mout et al.
ACS NANO (2017)
A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo
Chao Jiang et al.
CELL RESEARCH (2017)
Peptides for nucleic acid delivery
Taavi Lehto et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery
Cong-Fei Xu et al.
BIOMATERIALS (2016)
Programmed Self-Assembly of an Active P22-Cas9 Nanocarrier System
Shefah Qazi et al.
MOLECULAR PHARMACEUTICS (2016)
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Daniel P. Dever et al.
NATURE (2016)
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Alexis C. Komor et al.
NATURE (2016)
Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions
Sumiyo Morita et al.
NATURE BIOTECHNOLOGY (2016)
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
Hao Yin et al.
NATURE BIOTECHNOLOGY (2016)
CRISPR-Cas9-AID base editor is a powerful gain-of-function screening tool
Cem Kuscu et al.
NATURE METHODS (2016)
Immune cell screening of a nanoparticle library improves atherosclerosis therapy
Jun Tang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
Ming Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Translation dynamics of single mRNAs in live cells and neurons
Bin Wu et al.
SCIENCE (2016)
Advances in therapeutic CRISPR/Cas9 genome editing
Natasa Savic et al.
TRANSLATIONAL RESEARCH (2016)
RS-1 enhances CRISPR/Cas9-and TALEN-mediated knock-in efficiency
Jun Song et al.
NATURE COMMUNICATIONS (2016)
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice
Roman Maresch et al.
NATURE COMMUNICATIONS (2016)
Recent Progress of Microfluidics in Translational Applications
Zongbin Liu et al.
ADVANCED HEALTHCARE MATERIALS (2016)
Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing
Wujin Sun et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
Jesse G. Zalatan et al.
CELL (2015)
Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Chen Yu et al.
CELL STEM CELL (2015)
Delivery and therapeutic applications of gene editing technologies ZFNs, TALENs, and CRISPR/Cas9
Justin S. LaFountaine et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)
Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGEN
Qurrat Ul Ain et al.
JOURNAL OF CONTROLLED RELEASE (2015)
An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
Bin Li et al.
NANO LETTERS (2015)
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Silvana Konermann et al.
NATURE (2015)
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
Takeshi Maruyama et al.
NATURE BIOTECHNOLOGY (2015)
Therapeutic genome editing: prospects and challenges
David Benjamin Turitz Cox et al.
NATURE MEDICINE (2015)
Functional annotation of native enhancers with a Cas9-histone demethylase fusion
Nicola A. Kearns et al.
NATURE METHODS (2015)
Highly efficient Cas9-mediated transcriptional programming
Alejandro Chavez et al.
NATURE METHODS (2015)
High-throughput functional genomics using CRISPR-Cas9
Ophir Shalem et al.
NATURE REVIEWS GENETICS (2015)
Rational design of a split-Cas9 enzyme complex
Addison V. Wright et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation
Xin Han et al.
SCIENCE ADVANCES (2015)
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
John A. Zuris et al.
NATURE BIOTECHNOLOGY (2015)
Cell-Penetrating Peptides: Design, Synthesis, and Applications
Dana Maria Copolovici et al.
ACS NANO (2014)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu et al.
CELL (2014)
A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging
Marvin E. Tanenbaum et al.
CELL (2014)
Development and Applications of CRISPR-Cas9 for Genome Engineering
Patrick D. Hsu et al.
CELL (2014)
Breaking down the wall: the nuclear envelope during mitosis
Christine J. Smoyer et al.
CURRENT OPINION IN CELL BIOLOGY (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA
Suresh Ramakrishna et al.
GENOME RESEARCH (2014)
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
Sojung Kim et al.
GENOME RESEARCH (2014)
Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery
Wujin Sun et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
mRNA-based therapeutics - developing a new class of drugs
Ugur Sahin et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Engineering adeno-associated viruses for clinical gene therapy
Melissa A. Kotterman et al.
NATURE REVIEWS GENETICS (2014)
Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs
James A. Gagnon et al.
PLOS ONE (2014)
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
Yizhou Dong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
A fluorinated dendrimer achieves excellent gene transfection efficacy at extremely low nitrogen to phosphorus ratios
Mingming Wang et al.
NATURE COMMUNICATIONS (2014)
AAV-Mediated Gene Therapy for Research and Therapeutic Purposes
R. Jude Samulski et al.
ANNUAL REVIEW OF VIROLOGY, VOL 1 (2014)
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Lei S. Qi et al.
CELL (2013)
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
Luke A. Gilbert et al.
CELL (2013)
RNA-guided gene activation by CRISPR-Cas9-based transcription factors
Pablo Perez-Pinera et al.
NATURE METHODS (2013)
CRISPR RNA-guided activation of endogenous human genes
Morgan L. Maeder et al.
NATURE METHODS (2013)
Genome engineering using the CRISPR-Cas9 system
F. Ann Ran et al.
NATURE PROTOCOLS (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Thorlakur Jonsson et al.
NATURE (2012)
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Giedrius Gasiunas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy
Xian-Zhu Yang et al.
JOURNAL OF CONTROLLED RELEASE (2011)
Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L
Bart R. Anderson et al.
NUCLEIC ACIDS RESEARCH (2011)
Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity
Fu-Sen Liang et al.
SCIENCE SIGNALING (2011)
Ionic polypeptides with unusual helical stability
Hua Lu et al.
NATURE COMMUNICATIONS (2011)
Characterization of condensed plasmid DNA models for studying the direct effect of ionizing radiation
Mandi Tsoi et al.
BIOPHYSICAL CHEMISTRY (2010)
BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia
B. A. Burke et al.
LEUKEMIA (2010)
Effect of Genome Size on AAV Vector Packaging
Zhijian Wu et al.
MOLECULAR THERAPY (2010)
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
Josiane E. Garneau et al.
NATURE (2010)
Small CRISPR RNAs guide antiviral defense in prokaryotes
Stan J. J. Brouns et al.
SCIENCE (2008)
CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA
Luciano A. Marraffini et al.
SCIENCE (2008)
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou et al.
SCIENCE (2007)
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
A Bolotin et al.
MICROBIOLOGY-SGM (2005)
Packaging capacity of adeno-associated virus serotypes: Impact of larger genomes on infectivity and postentry steps
JC Grieger et al.
JOURNAL OF VIROLOGY (2005)
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
C Pourcel et al.
MICROBIOLOGY-SGM (2005)
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
FJM Mojica et al.
JOURNAL OF MOLECULAR EVOLUTION (2005)
Immune responses to gene therapy vectors: influence on vector function and effector mechanisms
N Bessis et al.
GENE THERAPY (2004)
Electronic detection of DNA by its intrinsic molecular charge
J Fritz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis
KS Makarova et al.
NUCLEIC ACIDS RESEARCH (2002)
Identification of genes that are associated with DNA repeats in prokaryotes
R Jansen et al.
MOLECULAR MICROBIOLOGY (2002)
A Toll-like receptor recognizes bacterial DNA
H Hemmi et al.
NATURE (2000)
Biological significance of a family of regularly spaced repeats in the genomes of Archaea, bacteria and mitochondria
FJM Mojica et al.
MOLECULAR MICROBIOLOGY (2000)